SELENIUM ALONE OR IN COMBINATION WITH LYCOPENE MODIFIES LIVER METABOLIZING ENZYMES AGAINST GALACTOSAMINE – A TIME BOUND STUDY
African Journal of Traditional, Complementary and Alternative Medicines · Volume 13, Issue 1 (2015) · pp. 169–175
Abstract
<jats:p>Background: Hepatitis is one of the major public health problems worldwide. This study was designed to evaluate the potential
hepatoprotective effects of lycopene (Lyco) and selenium (Se) against galactosamine (Gala) induced hepatitis in rats.
Materials and Methods: Seventy five (75) male albino rats were grouped into five of fifteen rats each. GP 1: Control. Animals in Groups (II-V)
were injected i.p with Gala (300 mg/kg b.w daily) for 5 days. GP III: Rats were orally pretreated with Lyco (15 mg/kg b.w). GP IV: rats were
pretreated orally sodium selenite (0.1 mg/kg b.w) by gavages. GP V: Rats treated with both Lyco and Se. The treatment was continuous for 30
days.
Results: The levels of serum inflammatory markers interleukine-6 (IL-6), tumor necrosis factor TNF- α, nitric oxide (NO) and malondialdhyde
(MDA) were markedly elevated in rats injected with Gala compared with control group. Administration of Lyco combined with Se reversed
these effects and significantly reduced the levels of these markers (p</jats:p>