An Overview of Transferosomes: A Transdermal Drug Delivery System

Abstract

<jats:p>A lipid bilayer including phospholipids, an edge activator, and an ethanol/aqueous core makes up transferosomes, often referred to as transferosomes, which are ultra-deformable vesicles for transdermal applications. Compared to oral and needle-based methods, this approach has a number of benefits, including self-administration, non-invasiveness, significantly reduced hepatic clearance of the medication, and increased patient compliance. The primary reason for the development of various drug delivery systems was that due to the first pass metabolism, adverse and side effects, non-patient compliance and invasive procedures, the efficient therapeutic outcomes. The advantage of transferosomes is they are barely invasive without the first pass metabolism. Transferosomes also has several advantages than liposomes due to the active surfactant properties. Due to its penetration enhancer properties, it enables the drug molecule to penetrate into the skin via the stratum corneum than other formulations. So, more research works are encouraged with respect to tranferosomes in order to formulate various new drugs in this type of drug delivery system.</jats:p>