Metformin effects on Polycystic Ovarian Syndrome

Abstract

<jats:p>Metformin treatment for polycystic ovarian syndrome (PCOS) is gaining popularity and acceptance, although clinical practice still outpaces research in this area. Although non-randomized trials with metformin have shown a broad variety of improvements in metabolic, reproductive, and clinical variables, a detailed examination of the findings from the studies with appropriate controls reveals that the benefits are limited. With a focus on the few randomized controlled trials, our goal in this descriptive review is to increase physicians' awareness of the published clinical data available, not to create practise recommendations. We also draw attention to additional concerns that need to be addressed before definitive therapeutic metformin may be prescribed for PCOS in order to treat different conditions. It also emphasises the possibility for larger gains from improvements in lifestyle alone. We anticipate that the evaluation will encourage more prudent use of metformin in PCOS patients.</jats:p>