Nelsonia canescens (Acanthaceae) aqueous extract and partitioned fractions ameliorates type-2 diabetes in alloxan-induced diabetic rats
Future Journal of Pharmaceutical Sciences · Volume 8, Issue 1 (2022)
Abstract
<jats:title>Abstract</jats:title><jats:sec>
<jats:title>Background</jats:title>
<jats:p>Diabetes mellitus is a metabolic disorder that affects the body’s ability to produce or use insulin. There is a continuous rise of this disease particularly in developing countries due to changes in life style and poverty among the people. In this study, antidiabetic activities of aqueous extract of <jats:italic>Nelsonia canescens</jats:italic> and its partitioned fractions in alloxan-induced diabetic rats were evaluated. Male albino rats were divided into 9 groups (diabetic and non-diabetic) of 5 rats each. Diabetes was induced by single intraperitoneal administration of alloxan (90 mg/kgbwt). The experimental design consists of a diabetic control group (untreated), a normal control group (1 mL saline), a standard diabetic drug (Glibenclamide; 5 mg/kgbwt), two doses (50 and 300 mg/kgbwt) of aqueous extract, ethyl acetate and methanol fractions of <jats:italic>Nelsonia canescens</jats:italic> were orally administered for a period 21 days. Blood glucose of the rats was monitored at 3-days intervals while biochemical and in vivo antioxidant assays of serum and liver were determined after 21 days.</jats:p>
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<jats:title>Results</jats:title>
<jats:p>The hypoglycemic effect of the extract observed was in a dose dependent manner with a significant reduction (<jats:italic>p</jats:italic> < 0.05) of blood glucose in ethylaceate fraction > aqueous extract > methanol fraction compared with the diabetic control group. A significant difference (<jats:italic>p</jats:italic> < 0.05) in lipid profiles and serum enzyme activity of rats in the diabetic control group was observed compared with the extract and fraction treated groups.</jats:p>
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<jats:title>Conclusion</jats:title>
<jats:p>The results suggest that the aqueous extract and fractions of <jats:italic>N. canescens</jats:italic> showed hypoglycemic and hypolipidemic potentials and significantly (<jats:italic>p</jats:italic> < 0.05) reduced the progression of oxidative stress.</jats:p>
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